منابع مشابه
Prime suspect.
Background: Human T-lymphotropic virus type-1 (HTLV-1) causes adult T-cell leukemia/ lymphoma and is linked to a number of lymphocyte-mediated disorders. HTLV-1 contains both regulatory and accessory genes in four pX open reading frames. pX ORF-II encodes two proteins, p13 and p30, whose roles are still being defined in the virus life cycle and in HTLV-1 virus-host cell interactions. Proviral c...
متن کاملTranscription: Identification of a prime suspect
Ever since its discovery, the sigma factor of Escherichia coli RNA polymerase has been held responsible for the initial promoter recognition that is an essential prerequisite for transcription of any gene. Without the complicity of the sigma factor, the core enzyme is unable to recognize the two major consensus sequences of a promoter — the –10 and –35 sequences — and the enzyme’s specificity f...
متن کاملParkinson's Disease: Return of an Old Prime Suspect
Pacemaking activity in adult substantia nigra (SN) dopamine neurons relies on L-type Ca2+ channels, but a surprising study in Nature by Chan et al. demonstrates that blockade of these channels by dihydropyridines re-establishes the pacemaking driven by sodium and HCN channels found in juvenile SN. This shift protects SN neurons in chemical models of Parkinson's disease (PD), suggesting that ele...
متن کاملPrime suspect: the TCF7L2 gene and type 2 diabetes risk.
Transcription factor-7-like 2 (TCF7L2) is the most important type 2 diabetes susceptibility gene identified to date, with common intronic variants strongly associated with diabetes in all major racial groups. This ubiquitous transcription factor in the Wnt signaling pathway was not previously known to be involved in glucose homeostasis, so defining the underlying mechanism(s) will provide new i...
متن کاملThe Mysteries of Chromosome Evolution in Gibbons: Methylation Is a Prime Suspect
Dobzhansky and Sturtevant provided the first view of the molecular basis of species identity in their 1938 seminal study classifying the chromosome rearrangements that distinguish two Drosophila species [1]. Decades of study of genome architecture from an evolutionary perspective then followed, enriching our knowledge of developmental genetics, gene regulation, human genetic disorders, and canc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1997
ISSN: 0091-6765
DOI: 10.2307/3433056